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目的:分析药物超敏综合征(DHS)致急性肾损伤(AKI)的临床特征。方法:选择确诊DHS 38例,根据是否发生AKI分为肾损伤组(观察组)15例,非肾损伤组(对照组)23例,回顾分析两组病史、实验室检查及辅助检查、临床表现及治疗转归,分析DHS致AKI的临床特点、易发因素等。结果:38例中,发生AKI 15例,发生率39.5%。观察组平均发病潜伏期、病程均显著长于对照组,发病前血肌酐水平显著高于对照组的4.3%(P<0.05);观察组病死率20.0%,显著高于对照组的4.3%(P<0.05)。结论:AKI在DHS的临床表现中,起病更隐匿,病程更易迁延,且是DHS患者死亡的高危因素。
Objective: To analyze the clinical features of acute renal injury (AKI) caused by drug-induced hypersensitivity syndrome (DHS). Methods: According to whether AKI occurred or not, 15 cases of renal injury group (observation group) and 23 cases of non-renal injury group (control group) were selected according to whether AKI occurred or not. The history, laboratory and auxiliary examination of two groups were retrospectively analyzed. And treatment outcome, analysis of DHS-induced AKI clinical features, predisposing factors. Results: In 38 cases, 15 cases occurred AKI, the incidence rate was 39.5%. The mean incubation period and duration of the observation group were significantly longer than those of the control group. The serum creatinine level before the onset was significantly higher than that of the control group (4.3%, P <0.05). The mortality of the observation group was 20.0%, significantly higher than that of the control group (4.3% 0.05). Conclusion: The clinical manifestation of AKI in DHS is more occult onset and the course of disease is more likely to be delayed. It is also a risk factor for the death of DHS.