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目的:观察厄贝沙坦治疗老年高血压左心室舒张功能障碍的疗效。方法:选择老年原发性高血压132例,分为观察组70例和对照组62例。观察组采用厄贝沙坦治疗,对照组采用依那普利治疗;依血压情况调整药量及辅助治疗药物,疗程均为6个月。采用多普勒超声测定治疗前后两组左心室舒张功能指标,并进行6min步行试验;比较两组总有效率。结果:观察组治疗后左心房内径(LAD)、二尖瓣舒张晚期流速(VA)显著或非常显著减少(降低),二尖瓣舒张早期流速(VE)、E/A、6min步行距离非常显著增加(P<0.05,P<0.01);观察组治疗后6min步行距离显著高于对照组(P<0.05)。观察组总有效率82.9%,非常显著高于对照组的66.1%(P<0.01)。结论:对于原发性高血压伴舒张功能不全患者,厄贝沙坦在改善左心室结构和功能方面优于依那普利。
Objective: To observe the efficacy of irbesartan in the treatment of left ventricular diastolic dysfunction in elderly patients with hypertension. Methods: 132 elderly patients with essential hypertension were selected and divided into observation group (70 cases) and control group (62 cases). The observation group was treated with irbesartan, the control group was treated with enalapril; the dose and adjuvant therapy were adjusted according to the blood pressure, and the course of treatment was 6 months. Doppler ultrasound before and after treatment of left ventricular diastolic function indicators, and 6min walk test; the two groups were compared the total efficiency. Results: The left atrial diameter (LAD) and the late mitral diastolic velocity (VA) in the observation group decreased significantly (P <0.05), and the mitral early diastolic velocity (VE), E / A, (P <0.05, P <0.01). The walking distance of the observation group at 6min after treatment was significantly higher than that of the control group (P <0.05). The total effective rate was 82.9% in the observation group, which was significantly higher than that in the control group (66.1%, P <0.01). CONCLUSIONS: Irbesartan is superior to enalapril in improving left ventricular structure and function in patients with essential hypertension and diastolic dysfunction.