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目的研究分析维生素D在2型糖尿病并发高血压中的发挥作用及其机制。方法选择45例2型糖尿病并发高血压患者设为甲组,选择同期患糖尿病而无高血压的患者45例以及健康体检者45例分别设为乙组和丙组。甲组、乙组患者服用维生素D,比较三组患者各项临床指标。结果甲组人25羟基维生素D3[25-(OH)D3]以及成纤维细胞生长因子(FGF)-23水平均比丙组、乙组低(P<0.05);根据Spearman相关分析,25-(OH)D3与FGF-23(r=-0.455,P<0.05)、糖化血红蛋白(Hb A1c)(r=-0.316,P<0.05)、空腹血糖(FPG)(r=-0.322,P<0.05)、收缩压(SBP)(r=-0.279,P<0.05)呈负相关。结论 2型糖尿病并发高血压的发病与维生素D有一定的联系,为该病的治疗提供了一条新的途径。
Objective To study the role and mechanism of vitamin D in type 2 diabetes complicated with hypertension. Methods Forty-five patients with type 2 diabetes complicated with hypertension were selected as group A, and 45 patients with diabetes mellitus without hypertension and 45 healthy subjects were selected as group B and group C respectively. Group A, Group B patients taking vitamin D, the clinical indicators of the three groups were compared. Results Compared with group C and group B, the levels of 25-hydroxyvitamin D3 [25- (OH) D3] and fibroblast growth factor (FGF-23) in group A were lower than those in group B and group B. According to Spearman correlation analysis, OH) D3 and FGF-23 (r = -0.455, P0.05), Hb A1c (r = -0.316, P <0.05), fasting plasma glucose (FPG) , Systolic blood pressure (SBP) (r = -0.279, P <0.05). Conclusion The incidence of type 2 diabetes complicated with hypertension has a certain relationship with vitamin D, which provides a new way for the treatment of this disease.