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巯甲丙脯酸(CPT),是一种特异性较高的血管紧张素转换酶(ACE)抑制剂,对慢性充血性心力衰竭(CHF)能产生有益的血液动力学改变和临床反应,现将临床应用中的有关问题分述如下: 一、血液动力学作用(一)急性期作用:据Levine报道病人在口服CPT以前3天停用所有的血管扩张剂,18小时前停用地高辛和利尿剂,低钠饮食,口服单剂量的CPT对CHF病人产生非常有益的血液动力学反应,口服CPT90分钟后右房压(RAP)从3.4降至0mmHg、肺毛细血管楔压(PCWP) 从22.7降至12.3mmHg、平均动脉压(MAP)从79.5
Captopril (CPT), a specific inhibitor of angiotensin converting enzyme (ACE), produces beneficial hemodynamic changes and clinical responses to chronic congestive heart failure (CHF) The clinical application of the issues are described below: First, the role of hemodynamics (A) the role of acute phase: According to Levine reported in patients with oral CPT 3 days before the withdrawal of all vasodilators, deactivation of digoxin 18 hours ago And diuretic, hyponatremia, and oral single-dose CPT produced a very beneficial haemodynamic response to CHF patients with a decrease in right atrial pressure (RAP) from 3.4 to 0 mmHg after 90 minutes of oral CPT. Pulmonary capillary wedge pressure (PCWP) decreased from 22.7 to 12.3 mmHg and mean arterial pressure (MAP) from 79.5