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自上世纪80年代以来,造血干细胞移植技术得到了飞速发展,在恶性血液病的治疗中取得了显著疗效,但供者选择、预处理强度、移植相关并发症如移植物抗宿主病(GVHD)及复发等问题仍然是当前面临的挑战。近年来蓬勃发展的单倍体移植及微移植技术在一定程度上克服了供者来源问题。单倍体移植仅需供受者之间有一条单倍体相合即可进行移植,任何患者均有可能在其原生家庭中找
Since the 1980s, hematopoietic stem cell transplantation has developed rapidly and has achieved remarkable results in the treatment of hematologic malignancies. However, donor selection, pretreatment intensity, graft-related complications such as graft-versus-host disease (GVHD) And recurrence and other issues remain the current challenges. In recent years, the rapid development of haploid transplantation and micro-transplantation technology to some extent to overcome the problem of donor sources. Haploids need only be haploidentically resectable to recipients for transplant, and any patient may be found in their primary family