论文部分内容阅读
高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)是心血管疾病的一个重要危险因素之一。流行病学研究表明勃起功能障碍(ED)与心血管疾病的发生密切相关。HHcy可能是ED的一个新的独立危险因素,HHcy导致ED的机制尚不十分清楚,可能与血管内皮细胞损伤、活性氧(ROS)、动脉粥样硬化等有关。HHcy与ED的关系仍需进一步研究,检测血浆Hcy和叶酸水平以及亚甲基四氢叶酸还原酶(MTHFR)基因型有助于ED诊断,尤其是对于年轻患者以及有心血管病家族史患者。对于HHcy伴ED患者的治疗,可先通过单独服用叶酸或结合维生素B6和维生素12来降低Hcy水平,然后进行5型磷酸二酯酶抑制剂(PDE5i)的治疗。本文就HHcy与ED的研究进展作一综述。
Hyperhomocysteinemia (Homocysteinemia) is one of the important risk factors of cardiovascular diseases. Epidemiological studies have shown that erectile dysfunction (ED) and cardiovascular disease are closely related. HHcy may be a new independent risk factor of ED. The mechanism of HHcy leading to ED is not yet clear, which may be related to vascular endothelial cell injury, reactive oxygen species (ROS), atherosclerosis and so on. The relationship between HHcy and ED remains to be further studied. Detection of plasma Hcy and folic acid levels and the genotype of methylenetetrahydrofolate reductase (MTHFR) may be useful for ED diagnosis, especially in younger patients and in patients with a family history of cardiovascular disease. For treatment of patients with HHcy with ED, Hcy levels may be reduced by taking folic acid alone or in combination with vitamin B6 and vitamin 12 followed by treatment with type 5 phosphodiesterase inhibitor (PDE5i). This article reviews the research progress of HHcy and ED.