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目的对耐多药肺结核患者进行纤维支气管镜介入治疗,分析其临床效果。方法 100例耐多药肺结核患者,随机分为观察组和对照组,各50例。对照组患者采用耐多药方案6Z Am Lfx PAS Pto/18Z Lfx PAS Pto治疗,观察组在对照组治疗基础上联合纤维支气管镜介入治疗。对比两组患者的临床治疗效果。结果治疗6个月后,观察组痰菌转阴率明显优于对照组(P<0.05);观察组病灶显效率、空洞闭合率分别为90.00%、88.00%,均优于对照组的74.00%、70.00%,差异均具有统计学意义(P<0.05)。结论纤维支气管镜介入治疗耐多药肺结核,临床效果显著,不良反应较少。
Objective To investigate the clinical effect of multi-drug resistant pulmonary tuberculosis patients treated with fiberoptic bronchoscopy. Methods 100 cases of MDR-TB patients were randomly divided into observation group and control group, 50 cases each. Patients in the control group were treated with the multidrug-resistant multi-drug regimen 6Z Am Lfx PAS Pto / 18Z Lfx PAS Pto, and the observation group was treated with bronchoscopic interventional therapy based on the control group. The clinical effects of two groups were compared. Results After 6 months of treatment, the rate of sputum negative conversion in the observation group was significantly better than that in the control group (P <0.05). The effective rate and void closure rate in the observation group were 90.00% and 88.00%, respectively, which were all better than those in the control group (74.00% , 70.00%, the difference was statistically significant (P <0.05). Conclusion The interventional therapy with bronchofibroscopes has multidrug-resistant pulmonary tuberculosis with significant clinical effect and few adverse reactions.