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微小RNA(miRNA)是一种内源性的单链RNA,含19～25个核苷酸,其在转录后水平与靶mRNA的3’非编码区相作用,通过抑制靶mRNA的翻译或降解靶mRNA来抑制基因的表达。近年来研究发现,miRNA在细胞的分化、增殖和凋亡等生理过程中发挥重要作用,其异常表达促使了多种疾病的发生和发展。B淋巴细胞是细胞免疫重要组成部分,大量的研究表明,miRNA参与B淋巴细胞的发育和B淋巴细胞肿瘤的发生。现就几年来关于miRNA-17-92簇、miRNA-150、miRNA-155和miRNA-181在正常B淋巴细胞发育过程中的表达情况及在B淋巴细胞肿瘤中异常变化的研究作一综述。
MicroRNA (miRNA) is an endogenous, single-stranded RNA containing 19-25 nucleotides that acts at the post-transcriptional level to the 3 ’non-coding region of the target mRNA by inhibiting the translation or degradation of the target mRNA Target mRNA to suppress gene expression. In recent years, it has been found that miRNA plays an important role in the physiological processes such as cell differentiation, proliferation and apoptosis, and its abnormal expression promotes the occurrence and development of various diseases. B lymphocytes is an important part of cellular immunity, a large number of studies have shown that miRNA involved in the development of B lymphocytes and B lymphocyte tumors. In recent years, we reviewed the expression of miRNA-17-92, miRNA-150, miRNA-155 and miRNA-181 in the development of normal B lymphocytes and their abnormal changes in B lymphocytic tumors in recent years.