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目的比较不同治疗方案对儿童急性重型再生障碍性贫血的疗效。方法根据不同治疗方案,将1996年1月-2011年11月收治的72例急性重型再生障碍性贫血患儿分为Ⅰ组[环孢素(CSA)+雄激素方案治疗组]54例、Ⅱ组[大剂量甲泼尼龙(HDMP)方案治疗组]10例、Ⅲ组(CSA+ATG方案治疗组)8例。按小儿再生障碍性贫血诊疗建议的疗效评定标准,比较3组间总有效率的差异。结果Ⅰ组、Ⅱ组和Ⅲ组总有效率分别为47.7%、60.0%和87.5%。Ⅱ组和Ⅲ组总有效率均高于Ⅰ组(χ2=5.806、6.394,Pa<0.05),Ⅲ组总有效率高于Ⅱ组(χ2=6.102,P<0.05)。结论以CSA+ATG联合方案治疗儿童急性重型再生障碍性贫血的疗效最佳。
Objective To compare the efficacy of different treatment regimens in children with acute severe aplastic anemia. Methods According to the different treatment plans, 72 children with acute severe aplastic anemia admitted from January 1996 to November 2011 were divided into group Ⅰ (n = 54) and group Ⅱ Group [high-dose methylprednisolone (HDMP) regimen treatment group] 10 cases, group Ⅲ (CSA + ATG regimen treatment group) 8 cases. According to pediatric aplastic anemia diagnosis and treatment recommendations for the evaluation criteria to compare the total efficiency of the three groups differences. Results The total effective rates of group Ⅰ, group Ⅱ and group Ⅲ were 47.7%, 60.0% and 87.5% respectively. The total effective rate of group Ⅱ and group Ⅲ were higher than that of group Ⅰ (χ2 = 5.806,6.394, Pa <0.05). The total effective rate of group Ⅲ was higher than that of group Ⅱ (χ2 = 6.102, P <0.05). Conclusion CSA + ATG combined treatment of children with acute aplastic anemia, the best effect.