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光敏剂血卟啉及其衍生物(HPD)可为癌组织吸收,并较长时间潴留。静脉注射用紫外光(400～410nm波长)照射,肿瘤产生红色荧光,用红光(620～640nm波长)照射肿瘤,通过光0000动力学作用,产生具细胞毒性的激发态氧,破坏癌细胞,为癌的定位诊断和治疗提供了一种新方法。近年随着激光和光导纤维系统的发展,治疗范围从表浅肿瘤,发展到某些深部肿瘤,诊治效果也有提高。本法由于简便易行,疗效较好,副作用小而为人瞩目。目前,光敏药物作用机理还缺乏深入了解:对药物在体内代谢和光量在不同组织及深度的吸收、分布和性质亦缺乏精确定量法,有待进一步完善。对HPD中生物有效成分还待进一步分离鉴别、
Photosensitizer hematoporphyrin and its derivatives (HPD) for cancer tissue absorption, and retention for a long time. Intravenous injection of ultraviolet light (400 ~ 410nm wavelength) irradiation, the tumor produces red fluorescence, with red light (620 ~ 640nm wavelength) irradiation of the tumor, through the light 0000 kinetic effect, produce cytotoxic excited oxygen, destroy cancer cells, It provides a new method for the diagnosis and treatment of cancer. In recent years, with the development of laser and optical fiber system, the treatment ranged from superficial tumors to deep tumors, and the diagnosis and treatment effects were also improved. Because of this law is simple, curative effect is good, the side effect is small and the person is attracted attention. At present, the mechanism of action of photosensitizers is still lack of understanding: the accurate quantification of the absorption, distribution and properties of drugs in the body metabolism and light intensity in different tissues and depths needs to be further improved. HPD in the bioactive ingredients to be further separated and identified,