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肌苷口服液的含量测定,浙江省药品标准用紫外分光光度法,但医院制剂室配制多剂量瓶装者,须加尼泊金乙酯作防腐剂(处方,肌苷10g,蔗糖250g、尼泊金乙酯0.5g,水至1000ml),从而干扰肌苷测定。由于两者吸收光谱组合特征,通常的分光光度法难以消除尼泊金的干扰和准确测定肌苷含量。笔者试用正交函数分光光度法的pi法测定其中肌苷含量,结果满意。仪器和试药 1.紫外分光光度计“上分”7520型用1cm石英池。 2.肌苷符合江苏省药品标准。 3.尼泊金乙酯符合中国药典1977版。 4.贮备液取105℃干燥至恒重的肌
Inosine oral solution content, Zhejiang Province, drug standards using UV spectrophotometry, but the preparation of multi-dose hospital preparation room bottler who should be used as a preservative of ethyl paraben (prescription, inosine 10g, 250g sugar, Gold ethyl ester 0.5g, water to 1000ml), interfering with inosine assay. Due to the combination of both spectral characteristics, it is difficult to eliminate the interference of nipagin by conventional spectrophotometry and determine the inosine content accurately. The author try orthogonal function spectrophotometry pi method for determination of inosine content, the results are satisfactory. Instruments and reagents 1. UV spectrophotometer “on the” 7520 type with 1cm quartz cell. Inosine in line with Jiangsu Province drug standards. 3. Nipagin ethyl ester in line with the Chinese Pharmacopoeia 1977 edition. 4. Stock solution to 105 ℃ drying to constant weight muscle