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复合型口服避孕药(OC)减弱妇女的葡萄糖耐量(GT)。作者近期研究OC也能减弱雌鼠GT。GT的改变可能是联合因素,如由于关键糖解酶磷酸果糖激酶(PFK)水平低和肌肉摄取的葡萄糖减少使糖酵解降低。作者研究目的是为了检查自雌鼠身上所观察的现象与人类状况的某些关联。
Compound oral contraceptives (OC) attenuate women’s glucose tolerance (GT). Recent research by the author OC can also weaken the female GT. Changes in GT may be a combination of factors such as decreased glycolysis due to low levels of the key glycolytic enzyme phosphofructokinase (PFK) and reduced muscle uptake of glucose. The purpose of the authors’ study was to examine some of the associations between the phenomena observed in female mice and human conditions.