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实验和临床均已证实出血性休克后常规的抗生素处理不能防止感染,鉴于出血性休克对宿主防御功能的损害作用,推测使用免疫促进剂或可降低创伤后感染的发生率。已知α肿瘤坏死因子(TNF)是在细菌和其它炎性刺激下由激活的巨噬细胞所产生,它具有改善免疫反应的关键作用,如增加单核细胞和多核白细胞的细胞毒性等等。γ干扰素是激活淋巴细胞的产物,具有调节免疫系统的重要功能。本实验观察TNF、γ干扰素以及两者对出血性休克后抗生素治疗的影响。取190～230g重雌性S-D成年鼠作为实验对象,放血使之发生出血性休克至动脉压45mmHg,45分钟后将血输回,并补充1.5倍的生理盐水。复苏后1小时在背部皮下注射1×10~8金葡菌接种物0.25ml,然后将动物分成7
Both experimental and clinical studies have shown that conventional antibiotic treatment does not prevent infection after hemorrhagic shock. In view of the damaging effect of hemorrhagic shock on host defense function, it is presumed that the use of an immunostimulant may reduce the incidence of post-traumatic infection. Alpha tumor necrosis factor (TNF) is known to be produced by activated macrophages under bacterial and other inflammatory stimuli and has the key role of improving the immune response, such as increasing the cytotoxicity of monocytes and polymorphonuclear leukocytes and the like. Interferon gamma is a product of activated lymphocytes and has an important function of regulating the immune system. The experimental observation of TNF, interferon γ and the impact of both antibiotics after hemorrhagic shock treatment. Take 190 ~ 230g females S-D adult rats as experimental subjects, bleeding to hemorrhagic shock to arterial pressure 45mmHg, 45 minutes after the blood is returned, and added 1.5 times the normal saline. One hour after the resuscitation, 0.25 ml of 1 x 10-8 S.aureus inoculum was injected subcutaneously in the back, and the animals were then divided into seven