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早在1953年即发现大剂量使用镇痛剂与慢性肾脏疾病之间存在着某种关联。尽管随后有许多报道,但镇痛剂是否为慢性肾脏疾病的病因却一直未获确证。为此,作者进行了一项多中心的病例对照研究。在北卡罗来纳州的同一地区中随机选出554例新诊断为慢性肾脏疾病(血清肌酐≥130nmol/L或1.5mg/dl)的患者及516例配对对照者。采用信函及电话询问了患者及对照者的镇痛剂(非那西汀,扑热息痛和阿斯匹林)使用史。进行逻辑回归分析。结果
As early as 1953, there was a correlation between the use of high-dose analgesics and chronic kidney disease. Despite the many reports that follow, the cause of whether or not an analgesic is chronic kidney disease remains unconfirmed. To do this, the authors conducted a multicentre case-control study. In the same area of North Carolina, 554 newly diagnosed patients with chronic kidney disease (serum creatinine ≥130 nmol / L or 1.5 mg / dl) and 516 matched controls were randomly selected. Patients and controls were asked about the use of analgesics (phenacetin, paracetamol, and aspirin) by letters and phone calls. Logistic regression analysis. result