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目的了解7-氨基头孢烷酸(7-ACA)致职业性哮喘的临床特点,为研究其发病机制提供依据。方法分析8例7-ACA致职业性哮喘患者的发病特点和临床资料。结果患者发病均有约数月到数年不等的潜伏期;病前期均出现过敏性鼻炎,或常伴有其他变态反应表现,临床类型均表现为速发型;哮喘早期发作与接触7-ACA明显相关,短时间、低浓度接触亦可致哮喘发作,脱离接触或假日不发病。结论早期诊断及早期治疗、及时脱离致哮喘工作场所是控制本病的关键。
Objective To investigate the clinical features of 7-aminocephalosporanic acid (7-ACA) induced occupational asthma and provide the basis for studying its pathogenesis. Methods Eight cases of 7-ACA caused by occupational asthma in patients with clinical features and clinical data. Results All patients had latent period of about several months to several years. Allergic rhinitis appeared in the early stage of the disease or often accompanied by other allergic reactions. The clinical manifestations were both immediate onset and early onset of asthma with 7-ACA exposure Related, short-term, low concentrations of exposure can also cause asthma attacks, from contact or holiday does not occur. Conclusion Early diagnosis and early treatment, timely release from the asthma workplace is the key to control the disease.