论文部分内容阅读
急性心肌梗塞溶栓治疗增加相关梗塞动脉以后再梗塞的危险性。对首次注入溶栓剂后平均5天(1～716天)重复溶栓治疗的31例患者进行效果和安全性评价。 病例和方法:选择31例全部为接受静脉溶栓治疗的AMI患者,男22例,女9例,平均年龄58±9岁。23例首次按受SKl50万u静注30min以上,8例给予t-PA100mg静注3h以上。重复接受SK13例,t-PA18例,剂量、方法同前。重复给药指征为长期胸痛伴新出现ST段抬高。 1 结果 22例在给药后平均8天血管造影术显示梗塞动脉再通,23例应用无创伤性标准(心肌梗塞后12h内血清肌酸激酶不再增高或达到峰值)评定疗效。心血管造影显示SK再次应用后70％梗塞动脉再通,t-PA应用后为75％。应用无创的方法分别为73％和75％。9例(29％)患者防止了再梗塞发生。
Acute myocardial infarction Thrombolytic therapy increases the risk of infarction after infarction. Thirty-one patients, who received repeated thrombolytic therapy for an average of five days (1-716 days) after initial thrombolytic therapy, were evaluated for efficacy and safety. Cases and Methods: Totally 31 AMI patients were treated with intravenous thrombolysis, 22 males and 9 females, with an average age of 58 ± 9 years. 23 cases for the first time by SKl50 million u intravenous injection 30min or more, 8 cases were given t-PA100mg intravenous 3h or more. Repeatedly accepted SK13 cases, t-PA18 cases, the dose, the same method. Repeat indications for long-term chest pain with new ST segment elevation. 1 Results 22 patients on average 8 days after administration of angiography showed recanalization of the artery, 23 cases of non-invasive criteria (12 h after myocardial infarction serum creatine kinase is no longer increased or peaked) to assess the efficacy. Cardiovascular angiography showed recanalization of 70% of the infarcted artery after SK reapplication, 75% after t-PA application. The application of noninvasive methods were 73% and 75% respectively. Nine patients (29%) prevented reinfarction.