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慢性血栓栓塞肺高血压(chronic thromboembolic pulmonary hypertension,CTEPH)患者右心功能不全与肺动脉内膜切除术后增加的发病率和死亡率相关。过往研究显示血浆脑钠尿肽水平与右心功能不全相关。研究人员假设脑钠尿肽可作为一个无创的生物标志物以确定术后发病率和死亡率高的“高危”患者。方法 :连续入选73例手术患者,研究其术后转归。根据先前制定的脑钠尿肽诊断标准将其分为3组:脑钠尿肽<11.5pmol/L表示右心功能正常(射血分数≥45%);脑钠尿肽>48.5pmol/L表示右心功能不全(右心射血分数<30%)和脑钠尿肽介于11.5～48.5pmol/L。术后
Right ventricular dysfunction in patients with chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased morbidity and mortality after pulmonary endarterectomy. Previous studies have shown that plasma brain natriuretic peptide levels associated with right ventricular dysfunction. The researchers hypothesized that brain natriuretic peptide may serve as a noninvasive biomarker to identify “high-risk” patients with high morbidity and mortality. Methods: A total of 73 surgical patients were enrolled and their postoperative outcomes were studied. According to the previously developed diagnostic criteria for brain natriuretic peptide will be divided into three groups: brain natriuretic peptide <11.5pmol / L that right heart function (ejection fraction ≥ 45%); brain natriuretic peptide> 48.5pmol / L said Right ventricular dysfunction (right heart ejection fraction <30%) and brain natriuretic peptide ranged from 11.5 to 48.5 pmol / L. After surgery