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本文研究了环氧司坦(epostane)对妊娠大鼠的止孕作用。环氧司坦48mg/kg灌胃给药,最佳给药时间为妊娠第10～11天。大鼠妊娠第10天,环氧司坦以48mg/kg灌胃给药或96mg/kg肌肉注射给药,均可使大鼠完全止孕。灌胃给药的ED_(50)为22.3±0.05mg/kg,95%可信限为17.3～28.8mg/kg;肌肉注射给药的ED_(50)为29.6±0.06mg/kg,95%可信限为22.0～39.5mg/kg。二者之间无显著差异(P>0.05)。环氧司坦对3β-羟甾脱氢酶具有抑制作用,黄体酮或消炎痛均可拮抗环氧司坦对大鼠的止孕作用,绒毛膜促性腺激素(hCG)不能拮抗环氧司坦对大鼠止孕作用。环氧司坦48mg/kg灌胃给药可使血浆孕酮水平下降,但无雌激素活性。
This article studies the effects of epostane on pregnant rats. Epothilone 48mg / kg intragastric administration, the optimal administration time for pregnancy 10 to 11 days. On the tenth day of gestation, oxystein was intragastrically administered at 48 mg / kg or intramuscularly at 96 mg / kg, all of which allowed complete conception in rats. The ED 50 of intragastric administration was 22.3 ± 0.05 mg / kg and the 95% confidence limit was 17.3-28.8 mg / kg. The ED 50 of intramuscular injection was 29.6 ± 0.06 mg / kg, 95% The credit limit is 22.0 ~ 39.5mg / kg. There was no significant difference between them (P> 0.05). Epothilone has an inhibitory effect on 3β-hydroxysteroid dehydrogenase, progesterone or indomethacin can antagonize the effect of cefoxitin on rats, and chorionic gonadotropin (hCG) can not antagonize the effects of epoxide On the role of Zhixin in rats. Oxytetrazine 48mg / kg intragastric administration of plasma progesterone levels can be reduced, but no estrogen activity.