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Objective:To clarify the prognostic value of post-treatment 18F-fluorodeoxyglucose(FDG) positron emission tomography(PET)/computed tomography(CT) in patients with advanced head and neck squamous cell carcinoma(HNSCC) after combined intra-arterial chemotherapy and radiotherapy(IACR).Methods:Thirty-six patients with HNSCC who underwent IACR were recruited.The period from the end of IACR to the last post-treatment 18F-FDG PET/CT examination was 8-12 weeks.Both patient-based and lesion-based analyses were used to evaluate the PET/CT images.For lesion-based analysis,36 regions(12 lesions of recurrences and 24 scars at primary sites) were selected.The Kaplan-Meier method was used to assess the overall survival(OS) stratified by 18F-FDG uptake or visual interpretation results.Results:Twelve patients with recurrence were identified by six months after IACR.The sensitivity and specificity in the patient-based analysis were 67%(8/12) and 88%(21/24),respectively.The mean OS was estimated to be 12.1 months(95% CI,6.3-18.0 months) for the higher maximum standardized uptake value(SUVmax) group(n=7) and 44.6 months(95% CI,39.9-49.3 months) for the lower SUVmax group(n=29).OS in the higher SUVmax group(cut-off point,6.1) or positive visual interpretation group was significantly shorter than that in the lower SUVmax or negative visual interpretation group(P<0.001 and P<0.05,respectively).Conclusions:The SUVmax and visual interpretation of HNSCC on post-IACR 18F-FDG PET/CT can provide prognostic survival estimates.
Objective: To clarify the prognostic value of post-treatment 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) / computed tomography (CT) in patients with advanced head and neck squamous cell carcinoma (HNSCC) after combined intra-arterial chemotherapy and radiotherapy (IACR). Methods: Thirty-six patients with HNSCC who underwent IACR were recruited. The period from the end of IACR to the last post-treatment 18F-FDG PET / CT examination was 8-12 weeks.Both patient-based and lesion -based analyzes were used to evaluate the PET / CT images. For lesion-based analysis, 36 regions (12 lesions of recurrences and 24 scars at primary sites) were selected. The Kaplan-Meier method was used to assess the overall survival (OS ) stratified by 18F-FDG uptake or visual interpretation results. Results: Twelve patients with recurrence were identified by six months after IACR. sensitivity and specificity in the patient-based analysis were 67% (8/12) and 88% (21 / 24), respectively. The mean OS was estimated to be 12 For the higher maximum standardized uptake value (SUVmax) group (n = 7) and 44.6 months (95% CI, 39.9-49.3 months) for the lower SUVmax group (n = 29). OS in the higher SUVmax group (cut-off point, 6.1) or positive visual interpretation group was significantly shorter than that in the lower SUVmax or negative visual interpretation group (P <0.001 and P <0.05, respectively) .Conclusions: The SUVmax and visual interpretation of HNSCC on post-IACR 18F-FDG PET / CT can provide prognostic survival estimates.