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作者检测了系统性红斑狼疮(SLE)患者外周血单个核细胞(PBMC)中 C-myc.Ki-ras 和Ha-ras 三种癌蛋白的表达和自然杀伤细胞(NK)亚群状况。结果显示,SLE 患者血液淋巴细胞和单核细胞中上述三种癌蛋白的阳性率均显著高亍健康对照组(P<0.001);而 SLE 组 NK 总数和CD16~+.CD16~+.57~+亚群细胞数则显著低于对照组(P<0.001)。作者结合文献讨论了 SLE 患者PBMC 中癌基因激活的可能机制和重要意义,以及与 NK 细胞和其亚群改变之间的相互关系。
The authors examined the expression of three oncoproteins C-myc. Ki-ras and Ha-ras and the status of natural killer (NK) subsets in peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE) The results showed that the positive rate of the three oncoproteins in blood lymphocytes and monocytes of SLE patients was significantly higher than that of the healthy control group (P <0.001), while the total number of NK cells and CD16 ~ + CD16 ~ + .57 ~ + Subpopulation cells was significantly lower than the control group (P <0.001). The authors discussed the possible mechanisms and significance of oncogene activation in PBMCs of patients with SLE and their relationship with alterations of NK cells and their subsets in combination with the literature.