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Knoevenagel缩合反应被广泛应用于合成香料、化工原料及药物中间体。离子液体作为反应溶剂,能促使一系列醛、酮与活泼亚甲基化合物的Knoevenagel缩合反应顺利进行。功能化离子液体作为催化剂成功催化Knoevenagel缩合反应,避免了使用额外催化剂。离子液体被认为是环境友好的“绿色”溶剂和“可设计”溶剂,为Knoevenagel缩合反应提供了高效、环保的制备途径。该文综述了离子液体在Knoevenagel缩合反应中的应用进展。
Knoevenagel condensation reaction is widely used in the synthesis of spices, chemical raw materials and pharmaceutical intermediates. Ionic liquid as a reaction solvent, can promote a series of aldehydes, ketones and active methylene compounds Knoevenagel condensation reaction smoothly. Functionalized ionic liquids successfully catalyze the Knoevenagel condensation reaction as a catalyst, avoiding the use of additional catalysts. Ionic liquids are considered environmentally friendly “green” solvents and “designable” solvents, providing an efficient and environmentally friendly preparation for Knoevenagel condensation reactions. This review summarizes the application of ionic liquids in the Knoevenagel condensation reaction.