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为研究内皮素（ＥＴ）在妊高征发病中的作用，我们用放射免疫测定法测定了２０例非孕妇女（未孕组）血浆，２０例正常晚期妊娠妇女（正常妊娠组）及４３例妊高征患者（妊高征组）血浆、胎儿脐血、羊水中ＥＴ－１的水平，结果表明：正常妊娠组血浆ＥＴ－１值高于未孕组，妊高征组中、重症病例血浆ＥＴ－１显著高于正常妊娠组和轻症病例（Ｐ＜００１），且羊水、脐血中ＥＴ－１均高于母血浆中水平。提示：（１）妊娠时ＥＴ－１对母体及胎儿循环有调节作用。（２）ＥＴ－１水平升高可能在妊高征发病及病理变化中有重要作用，并且与疾病的严重程度有关。（３）羊水、脐血中有一定水平的ＥＴ－１，妊高征时，它们出现相应变化，在其发病中同样起到一定作用
To investigate the role of endothelin (ET) in the pathogenesis of PIH, we measured the plasma levels of 20 non-pregnant women (nontreated group), 20 normal late pregnant women (normal pregnancy group) and 43 normal pregnant women by radioimmunoassay PIH patients (PIH) plasma, fetal cord blood, amniotic fluid levels of ET-1, the results showed that: normal pregnancy group plasma ET-1 value was higher than the non-pregnant group, PIH group, severe cases of plasma ET-1 was significantly higher than normal pregnancy group and mild cases (P <001), and amniotic fluid, cord blood ET-1 were higher than the level in maternal plasma. Tip: (1) ET-1 during pregnancy can regulate maternal and fetal circulation. (2) Elevated ET-1 level may play an important role in the pathogenesis and pathological changes of PIH, and is related to the severity of the disease. (3) amniotic fluid, umbilical cord blood in a certain level of ET-1, PIH, they appear corresponding changes in the pathogenesis also play a role