糖尿病患者钙磷调节激素和cAMP之变化及临床意义探讨

• 作 者: 王育敏 张仲才 刘桂花 王嘉军 王华星
• 机 构: 空军兰州医院核医学室,空军兰州医院核医学室,空军兰州医院核医学室,空军兰州医院核医学室,空军兰州医院核医学室,
• 出 处: 宁夏医学杂志
• 发表日期: 1993年03期
• 关键词: 调节激素 降钙素 环核苷酸 甲状旁腺激素 胰岛素原 健康献血员 放射免疫分析法 破骨细胞 磷代谢性疾病 外源性胰岛素

借助放射免疫分析法,检测了75例糖尿病患者血浆中C-肽、25-OH维生素D_3(25-OHD_3)、降钙素、甲状旁腺激素-M(PTH-M)及cAMP的变化,并探讨这些变化与糖尿病性骨质疏松的关系。结果表明,糖尿病患者与健康献血员比较,C-肽和降钙素水平显著低降(P<0.05),PTH-M和cAMP水平显著居高(P<0.05),两组之25-OHD_3水平无显著差异(P>0.05);且C-肽水平与降钙素呈显著正相关,与PTH-M呈显著负相关,提示降钙素、PTH-M和cAMP的改变在糖尿病性骨质疏松的发病机理中起着重要作用。

The levels of C-peptide, 25-OH vitamin D 3 (25-OHD 3), calcitonin, parathyroid hormone-M (PTH-M) and cAMP in 75 diabetic patients were detected by radioimmunoassay To explore the relationship between these changes and diabetic osteoporosis. The results showed that the levels of C-peptide and calcitonin were significantly lower (P <0.05) and the levels of PTH-M and cAMP were significantly higher in diabetic patients than healthy blood donors (P <0.05). The levels of 25-OHD 3 (P> 0.05). The level of C-peptide was positively correlated with calcitonin and negatively correlated with PTH-M, suggesting that the changes of calcitonin, PTH-M and cAMP in diabetic osteoporosis The pathogenesis plays an important role.