论文部分内容阅读
目的:探讨抗核糖体P蛋白(Rib-P)及亚型(Rib-P0、P1和P2)抗体在系统性红斑狼疮(SLE)中的诊断价值。方法:分别检测375例SLE患者血清中的抗Rib-P、P0、P1和P2抗体,分析抗Rib-P系列抗体在SLE诊断中的意义。结果:(1)抗Rib-P、P0、P1和P2抗体的敏感性分别为:32.8%、39.4%、55.1%和37.4%,特异性分别97.7%、97.7%、95.5%和94.9%。SLE患者血清中抗Rib系列抗体的敏感性和特异性无统计学差异。(2)抗Rib-P0、P1、P2抗体在133例抗Rib-P抗体阴性的SLE中阳性率分别为18.0%、36.1%和15.8%。抗dsDNA抗体或抗Sm抗体阴性的SLE中有20.3%～44.6%的抗Rib-P系列抗体呈阳性。(3)抗Rib-P0,P1,P2蛋白抗体中阳性组狼疮精神损害的发生率均高于阴性组(P<0.05)。其中抗Rib-P和P2抗体阳性组的发生率显著高于阴性组(P<0.01)。结论:抗Rib-P蛋白及亚型抗体均为SLE特异性的自身抗体,该系列抗体对抗dsDNA抗体或抗Sm抗体阴性的SLE患者诊断有参考意义,并且与狼疮精神损害相关。
Objective: To investigate the diagnostic value of anti-ribosomal P-protein (Rib-P) and subtype (Rib-P0, P1 and P2) antibodies in systemic lupus erythematosus (SLE). Methods: The anti-Rib-P, P0, P1 and P2 antibodies in serum of 375 patients with SLE were detected, and the significance of anti-Rib-P antibodies in diagnosis of SLE was analyzed. Results: (1) The sensitivity of anti-Rib-P, P0, P1 and P2 antibodies were 32.8%, 39.4%, 55.1% and 37.4% respectively, and the specificity was 97.7%, 97.7%, 95.5% and 94.9% respectively. There was no statistical difference in the sensitivity and specificity of anti-Rib antibodies in SLE patients. (2) The positive rates of anti-Rib-P0, P1, P2 antibodies were 18.0%, 36.1% and 15.8% in 133 anti-Rib-P antibody negative SLE patients respectively. 20.3% to 44.6% of anti-Rib-P antibodies were positive in anti-dsDNA or anti-Sm antibody-negative SLE. (3) The incidence of mental damage of positive lupus in the anti-Rib-P0, P1, P2 antibody was higher than that in the negative group (P <0.05). The incidence of anti-Rib-P and P2 antibody-positive group was significantly higher than that of negative group (P <0.01). CONCLUSION: Anti-Rib-P protein and subtype antibodies are SLE-specific autoantibodies. This series of antibodies is of diagnostic value for anti-dsDNA or anti-Sm antibody-negative patients with SLE and is associated with mental impairment of lupus.