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目的 研究粘着斑激酶 (FAK)表达与乳腺癌生物学行为和预后的关系。方法 应用免疫组织化学 S-P方法检测 1 1 5例乳腺癌手术标本中 FAK的表达情况。结果 乳腺癌原发灶 FAK表达阳性率为 81 .74 % ,其中无区域淋巴结转移者阳性率为 6 4 .4 4 % ,有区域淋巴结转移者阳性率为 92 .86 % (P<0 .0 1 ) ,FAK表达水平与乳腺癌大小和 p TNM分期进展呈正相关 (P<0 .0 1 ,P<0 .0 1 )。FAK阳性者术后 3年、 5年生存率分别为 6 5 .96 %、 4 5 .39% ,而阴性者为 76 .1 9%、 6 0 .6 1 % ;两组患者术后 3年、 5年生存率差别均有显著性 (P<0 .0 5 ,P<0 .0 5 )。结论 乳腺癌组织由于 FAK表达增加 ,导致恶性细胞的发生、增殖、浸润和转移。故检测乳腺癌组织中 FAK表达状况 ,有助于进一步了解乳腺癌生物学行为和对患者预后的判断
Objective To study the relationship between the expression of focal adhesion kinase (FAK) and the biological behavior and prognosis of breast cancer. Methods Immunohistochemical S-P method was used to detect the expression of FAK in 115 cases of breast cancer. Results The positive rate of FAK expression in primary breast cancer was 81.74%. The positive rate of FAK in non-regional lymph node metastasis was 6.44%, and the positive rate of regional lymph node metastasis was 92.86% (P <0. 0) 1). FAK expression was positively correlated with breast cancer size and p TNM stage (P <0.01, P <0.01). The 3-year and 5-year survival rates of FAK positive patients were 65.96% and 45.39%, respectively, while those of negative patients were 76.119% and 60.1%. The postoperative 3 years , 5-year survival rates were significantly different (P <0. 05, P <0. 05). Conclusion The increase of FAK expression in breast cancer tissue leads to the occurrence, proliferation, infiltration and metastasis of malignant cells. Therefore, the detection of FAK expression in breast cancer tissue is helpful to further understand the biological behavior of breast cancer and to judge the prognosis of patients