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目的了解2009年我国首例甲型H1N1流感二代病例的流行病学、临床、病原学检查特点及预后转归。方法对患者流行病学及临床资料进行回顾性分析,并采用实时荧光聚合酶链反应测定甲型H1N1流感病毒核酸。结果患者与甲型H1N1流感输入病例接触1天后发病。以发热、咽痛、咳嗽起病,白细胞及CD4+T淋巴细胞计数降低,无肺炎等并发症。多级机构检测咽拭子甲型H1N1流感病毒核酸阳性确诊甲型H1N1流感。RT-PCR测序证实其病毒核苷酸序列与一代输入病例的一致,同源性为100%。经奥司他韦抗病毒及对症治疗痊愈出院。结论本病例的传染源明确,为我国首例报告的甲型H1N1流感二代确诊病例,其临床表现轻,病情恢复快。未发生院内感染,早隔离早诊断等防控措施有效。
Objective To understand the epidemiological, clinical and etiological characteristics and prognosis of the first case of type A H1N1 influenza in China in 2009. Methods The epidemiological and clinical data of patients were retrospectively analyzed, and the nucleic acid of Influenza A (H1N1) virus was determined by real-time fluorescence polymerase chain reaction. Results The patient was infected with the imported H1N1 flu case one day later. To fever, sore throat, cough onset, lower leukocyte and CD4 + T lymphocyte count, no complications such as pneumonia. Multi-level detection of swine influenza A H1N1 influenza virus nucleic acid positive type A H1N1 influenza. RT-PCR analysis confirmed that the nucleotide sequence of the virus was identical with that of the first generation of imported samples with 100% homology. After oseltamivir antivirus and symptomatic treatment were cured. Conclusion The source of infection in this case is clear. It is the first reported case of the second generation of Influenza A (H1N1) influenza in our country. The clinical manifestations are mild and the disease recovered quickly. No nosocomial infection, early isolation and early diagnosis and other prevention and control measures effective.