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“肝肾综合征”这一术语,传统地被用于肝胆疾病引起的肾功能衰竭。肾功能衰竭的发病机理还有争论,认为可归咎于下列因素,包括缺氧症、内毒素、微血管血栓、止血异常等,常合并有肾和肝功能衰竭。作者通过在黄疸鼠肾脏内同位素标记的纤维蛋白原沉积的研究,审查了肾脏内微血栓形成的假设。 40只Wistar雄鼠(300～350g)。注射100μCi同源性~(125)Ⅰ纤维蛋白原,25只在乙醚麻醉下作总胆管结扎和切除(黄疸组)。在手术时从左肾静脉采血2ml,以测定尿素、胆红素及放射活性(RA/ml),后切除左肾、测定其重量和器官内的放射活性并用RA/mg来表示。之后鼠逐渐恢复并给予足够的食物和水供其尽可能摄食。10只鼠在一周内无尿而死亡。它们不作为分析的资料。一周后再次手术,从右肾静脉取血2ml测定尿
The term “hepatorenal syndrome” is traditionally used for kidney failure caused by hepatobiliary disease. The pathogenesis of renal failure is still debated, arguing that the following factors can be attributed, including hypoxia, endotoxin, microvascular thrombosis, hemostatic abnormalities, often associated with kidney and liver failure. The authors examined the hypothesis of micro-thrombosis in the kidney through a study of isotope-labeled fibrinogen deposition in the kidney of jaundice rats. 40 Wistar male rats (300-350 g). 100 μCi homology ~ (125) Ⅰ fibrinogen was injected into the abdominal cavity. Twenty-five bile duct ligation and resection were performed under anesthesia with ether (jaundice group). Blood was drawn from the left renal vein at the time of surgery to measure urea, bilirubin and radioactivity (RA / ml). The left kidney was resected and its weight and intra-organ radioactivity were measured and expressed as RA / mg. After that, the rats gradually recovered and given enough food and water for their feeding as much as possible. Ten rats died without urine within a week. They are not used as analytical data. A week later surgery, blood from the right renal vein 2ml determination of urine