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目的:探讨HPV感染阴性的子宫颈鳞状细胞癌(CSC)中PCNA、PMAPK、MMP-9、β-integrin的表达及其与侵袭、转移的关系。方法:采用免疫组织化学SP法检测经PCR方法筛选出17例HPV感染阴性CSC及20例HPV感染阳性CSC的标本中PCNA、PMAPK、MMP-9、β-integrin的表达;应用图像分析软件分别对4种抗体的表达进行分析。结果:HPV阴性CSC组PCNA、PMAPK、MMP-9、β-integrin的表达水平与HPV阳性CSC组的表达水平差异无统计学意义(P>0.05)。结论:HPV阴性CSC和HPV阳性CSC的生物学特点相似,均具有较强的侵袭、转移特性,说明CSC的生物学特性及预后与HPV感染无直接相关性。
Objective: To investigate the expression of PCNA, PMAPK, MMP-9, β-integrin and their relationship with invasion and metastasis in human papillomavirus (HPV) -negative cervical squamous cell carcinoma (CSC) Methods: The expression of PCNA, PMAPK, MMP-9, and β-integrin in 17 specimens of HPV-negative CSC and 20 specimens of HPV-positive CSC were screened by immunohistochemical SP method by PCR method. 4 kinds of antibody expression analysis. Results: The expression levels of PCNA, PMAPK, MMP-9 and β-integrin in HPV-negative CSC group were not significantly different from those in HPV-positive CSC group (P> 0.05). Conclusion: The biological characteristics of HPV-negative CSC and HPV-positive CSC are similar, all of which have strong invasion and metastasis characteristics, indicating that the biological characteristics and prognosis of CSC have no direct correlation with HPV infection.