保留交感神经的高选择性迷走神经切断术—动物模型的建立

• 作 者: 刘民生 高春芳 黎介寿 邹忠寿
• 机 构: 解放军一五○中心医院外五科,南京军区南京总医院普通外科研究所
• 出 处: 普外临床
• 发表日期: 1997年03期
• 关键词: 动物模型 迷走神经切断术 大鼠 胃小弯 拉氏神经 胃左动脉 去甲肾上腺素 动物实验模型 分布密度 胃酸分泌

保留交感神经的高选择性迷走神经切断术（ＨＳＶＡＰ）手术方法是在高选择性迷走神经切断术（ＨＳＶ）基础上，保留胃小弯的血管，从而保留了支配胃的交感神经。６０只雄性ＳＤ大鼠随机分为三组：ＨＳＶＡＰ组、ＨＳＶ组和正常对照组（Ｃ组），每组２０只。ＨＳＶＡＰ术后胃部泌酸区交感神经分布密度与Ｃ组比较，下降不显著。去甲肾上腺素含量与Ｃ组无差别（７４５８±４０８９ｖｓ８９９６±２３５１，Ｐ＞００５）。而ＨＳＶ术后胃部泌酸区交感神经分布密度显著下降，去甲肾上腺素含量低于ＨＳＶＡＰ术后（２９３±２１４８ｖｓ７４５８±４０８９，Ｐ＜００１）。本试验证实采用保留胃小弯血管的ＨＳＶ，既可完全切断支配胃体的迷走神经，又可保留交感神经。

The preservation of the sympathetic highly selective vagotomy (HSV AP) surgical approach is based on high-selective vagotomy (HSV), retaining the blood vessels of the lesser curvature, which retains the stomach dominated the sympathetic. Sixty male SD rats were randomly divided into three groups: HSV AP group, HSV group and normal control group (C group), 20 in each group. HSV  AP postoperative gastric acid zone sympathetic distribution density compared with the C group, the decline was not significant. Norepinephrine content and C group no difference (745.8 ± 4089vs8996 ± 2351, P> 005). However, the density of sympathetic nerves in gastric acid district significantly decreased after HSV, and the content of norepinephrine was lower than that of HSVAP after operation (293 ± 2148vs7458 ± 4089, P <001). This experiment confirmed that the use of retained gastric lesser vascularity of HSV, both completely control the vagus nerve dominate the body, but also retain the sympathetic.