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喹诺酮类药物在体外对伤寒和副伤寒杆菌高度有效。口服环丙氟哌酸吸收好、血浓度高,在胆汁和细胞中均可达到高浓度。最近西德东伯明翰医院临床指出,30例伤寒患者(其中男性23例。年龄16～62岁,平均31.3岁,17株伤寒杆菌、11株副伤寒杆菌A、2株副伤寒杆菌B)中16例口服环丙氟哌酸500mg(每日2次)治疗,其余患者开始静脉给药(200mg,每日2次,平均3.4天,范围2～10天)后改为口服继续治疗。22例治疗14天,8例治疗10天。所有患者对治疗的反映
Quinolones are highly effective against typhoid and paratyphoid bacilli in vitro. Oral ciprofloxacin good absorption, high blood concentration, both in bile and cells can reach high concentrations. Recently, West Germany East Birmingham Hospital clinical pointed out that 30 cases of typhoid patients (23 males, aged 16 to 62 years, an average of 31.3 years old, 17 strains of Salmonella typhi, 11 strains of paratyphoid A, 2 strains of paratyphoid A), 16 Cases of oral ciprofloxacin 500mg (twice daily) treatment, the remaining patients started intravenous (200mg, 2 times a day, an average of 3.4 days, range 2 to 10 days) to oral continued treatment. 22 cases of treatment for 14 days, 8 cases of treatment for 10 days. All patients reflect the treatment