【摘 要】
：
A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk.In humans,a large proportion of mental disorders are accompanied by impairments in risk avoidance.One of the most important genes involved in men
【机 构】
：
Guangdong Provincial Key Laboratory of Brain Connectome and Behavior,CAS Key Laboratory of Brain Con
论文部分内容阅读
A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk.In humans,a large proportion of mental disorders are accompanied by impairments in risk avoidance.One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1),and animal models in which this gene has some level of dysfunction show emotion-related impairments.However,it is not known whether DISC1 mouse models have an impairment in avoiding potential risks.In the present study,we used DISC1-N terminal truncation (DISC1-NTM) mice to inves-tigate risk avoidance and found that these mice were impaired in risk avoidance on the elevated plus maze(EPM) and showed reduced social preference in a three-chamber social interaction test.Following EPM tests,c-Fos expression levels indicated that the nucleus accumbens(NAc) was associated with risk-avoidance behavior in DISC1-NTM mice.In addition,in vivo electrophysiological recordings following tamoxifen administration showed that the firing rates of fast-spiking neurons (FS) in the NAc were significantly lower in DISC1-NTM mice than in wild-type (WT) mice.In addition,in vitro patch clamp recording revealed that the frequency of action potentials stimulated by current injection was lower in parvalbumin (PV)neurons in the NAc of DISC1-NTM mice than in WT controls.The impairment of risk avoidance in DISC1-NTM mice was rescued using optogenetic tools that activated NAcPV neurons.Finally,inhibition of the activity of NAcPV neurons in PV-Cre mice mimicked the risk-avoidance impairment found in DISC1-NTM mice during tests on the elevated zero maze.Taken together,our findings confirm an impairment in risk avoidance in DISC1-NTM mice and suggest that reduced excitability of NAcPV neurons is responsible.
其他文献
The cerebellum is conceptualized as a processor of complex movements and is also endowed with roles in cognitive and emotional behaviors.Although the axons of deep cerebellar nuclei are known to project to primary thalamic nuclei,macroscopic investigation
Mechanosensitive ion channels (MSCs) are key molecules in the mechano-electrical transduction of arterial baroreceptors.Among them,acid-sensing ion channel 2(ASIC2) and transient receptor potential vanilloid subfam-ily member 1 (TRPV1) have been studied e
Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor-β superfamily.It is widely distributed in the central and peripheral nervous systems.Whether and how GDF-15 modulates nociceptive signaling remains unclear.Behaviorall
Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development.Lappaconitine(LA),a potent analgesic drug extracted from the root of natural Aco
The exacerbation of progressive multiple scle-rosis (MS) is closely associated with obstruction of the differentiation of oligodendrocyte progenitor cells (OPCs).To discover novel therapeutic compounds for enhancing remyelination by endogenous OPCs,we scr
Food deprivation can rescue obesity and over-weight-induced mood disorders,and promote mood per-formance in normal subjects.Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction,but little is known about
Our previous investigation suggested that faster seventh cervical nerve(C7)regeneration occurs in patients with cerebral injury undergoing contralateral C7 transfer.This finding needed further verification,and the mecha-nism remained largely unknown.Here,
Dear Editor,rnNeuropathic pain (NeuP) is known as a common and notorious neurological disease,characterized by sponta-neous pain and evoked abnormal pain that includes hypersensitivity to external innocuous (allodynia) and noxious stimulation (hyperalgesi
Dear Editor,rnInflammatory pain,such as arthritic pain,is a common health problem worldwide.Inflammatory pain is generally treated by opioids and non-steroidal anti-inflammatory drugs including cyclooxygenase-2 (COX-2) inhibitors.However,side-effects limi
Dear Editor,rnItch (pruritus) is an unpleasant somatic sensation that is accompanied by the desire to scratch.While itch provides a warning signal that protects us from potential threats in normal conditions,severe or chronic itch associated with dermatos