【摘 要】
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The exacerbation of progressive multiple scle-rosis (MS) is closely associated with obstruction of the differentiation of oligodendrocyte progenitor cells (OPCs).To discover novel therapeutic compounds for enhancing remyelination by endogenous OPCs,we scr
【机 构】
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Institute of Neuroscience,Key Laboratory of Molecular Neurobiology of the Ministry of Education and
论文部分内容阅读
The exacerbation of progressive multiple scle-rosis (MS) is closely associated with obstruction of the differentiation of oligodendrocyte progenitor cells (OPCs).To discover novel therapeutic compounds for enhancing remyelination by endogenous OPCs,we screened for myelin basic protein expression using cultured rat OPCs and a library of small-molecule compounds.One of the most effective drugs was pinocembrin,which remarkably promoted OPC differentiation and maturation without affecting cell proliferation and survival.Based on these in vitro effects,we further assessed the therapeutic effects of pinocembrin in animal models of demyelinating dis-eases.We demonstrated that pinocembrin significantly ameliorated the progression of experimental autoimmune encephalomyelitis (EAE) and enhanced the repair of demyelination in lysolectin-induced lesions.Further stud-ies indicated that pinocembrin increased the phosphorylation level of mammalian target of rapamycin(mTOR).Taken together,our results demonstrated that pinocembrin promotes OPC differentiation and remyelina-tion through the phosphorylated mTOR pathway,and suggest a novel therapeutic prospect for this natural flavonoid product in treating demyelinating diseases.
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