【摘 要】
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Food deprivation can rescue obesity and over-weight-induced mood disorders,and promote mood per-formance in normal subjects.Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction,but little is known about
【机 构】
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State Key Laboratory of Organ Failure Research,Key Laboratory of Mental Health of the Ministry of Ed
论文部分内容阅读
Food deprivation can rescue obesity and over-weight-induced mood disorders,and promote mood per-formance in normal subjects.Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction,but little is known about the mechanism of calorie restriction-induced mood modification.Previous studies have found that astrocytes modulate depressive-like behaviors.Inositol 1,4,5-trisphosphate receptor type 2(IP3R2) is the predominant isoform in mediating astrocyte Ca2+ signals and its genetic knockout mice are widely used to study astrocyte function in vivo.In this study,we showed that deletion of IP3R2 blocked the antidepressant-like effect induced by calorie restriction.In vivo micro-dialysis experiments demonstrated that calorie restriction induced an increase in ATP level in the medial prefrontal cortex (mPFC) in na(i)ve mice but this effect disappeared in IP3R2-knockout mice,suggesting a role of astrocytic ATP in the calorie restriction-induced antidepressant effect.Further experiments showed that systemic administration and local infusion of ATP into the mPFC induced an antidepressant effect,whereas decreasing ATP by Apyrase in the mPFC blocked calorie restriction-induced antide-pressant regulation.Together,these findings support a role for astrocytic ATP in the antidepressant-like effect caused by calorie restriction.
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