论文部分内容阅读
为寻找高效低毒、结构简单的鬼臼毒素类新药,以4-溴-4′-去甲基-4-脱氧表鬼臼毒素和过量醇合成了13个新的4′-去甲基表鬼臼毒素-4-醚衍生物。所有这些化合物对体外 L1210试验,均有抑制活性,其中5个化合物的抑制活性与 etoposide 相近。
In order to find a new potent and potent inhibitor of podophyllotoxins with high activity and low toxicity, thirteen new 4’-demethyl groups were synthesized from 4-bromo-4’-demethyl-4-deoxypodophyllotoxin and excess alcohol Podophyllotoxin-4-ether derivatives. All of these compounds have inhibitory activity against L1210 in vitro, of which 5 compounds have similar inhibitory activity to etoposide.