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一些临床试验提示阿司匹林抗栓作用限于男性。为了验证阿司匹林抑制血小板作用的性别差异,作者运用体外全血血小板凝集检测法,对男性和女性志愿者以及接受激素治疗的前列腺癌患者进行研究。资料和方法女性志愿者29例(平均年龄39岁);男性志愿者25例(平均年龄47岁);前列腺癌患者36例(平均年龄71岁),其中15例作了睾丸切除术,6例接受雌激素治疗。所有受试者在检测前至少1～2周未服用过阿司匹林或其它抗血小板药物。无一例妊娠或口服避孕药的妇女。无一例在测试当天吸烟。全血标本用3.8%枸椽酸钠抗凝,加
Some clinical trials suggest that aspirin antithrombotic effects are limited to men. To test the gender difference in aspirin’s inhibition of platelet function, the authors used in vitro whole blood platelet aggregation assays to study male and female volunteers and those with hormone-treated prostate cancer. Materials and Methods There were 29 female volunteers (mean age 39 years), 25 male volunteers (mean age 47 years), 36 prostate cancer patients (mean age 71 years), of which 15 had orchiectomy and 6 Estrogen therapy. All subjects had not taken aspirin or other antiplatelet medications at least 1 to 2 weeks prior to testing. No case of pregnancy or oral contraceptives for women. None of them smoked on the day of the test. Whole blood samples with 3.8% sodium citrate anticoagulant, plus