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56名患者服阿霉素(第一天静注40毫克/米~2),第三天及第六天口服环磷酰胺200毫克/米~2对48名患者进行至少两个疗程治疗(相隔3—4周)。对其疗效可作出估计。给予阿霉素总剂量为500毫克/米~2之后,维持口服环磷酰胺(第1至5天,200毫克/米~2/天)。静注长春新硷(第一天1.0毫克/米~2;最大剂量2毫克)及氨甲喋呤(第一天45毫克/米~2)每3～4周重复用药。有效应的小细胞癌患者在用阿霉素与环磷酰胺的第二疗程同时接受
Fifty-six patients received doxorubicin (40 mg / m 2 on day 1) and 48 mg / m 2 on day three and day 6 for at least two courses of treatment 3-4 weeks). Its efficacy can be estimated. Cyclophosphamide was administered orally (Day 1 to Day 5, 200 mg / m ~ 2 / day) after giving a total dose of doxorubicin of 500 mg / m 2. Intravenous injection of vincristine (1.0 mg / m 2 on day 1; maximal dose of 2 mg) and methotrexate (45 mg / m 2 on day 1) were repeated every 3 to 4 weeks. Effective small cell lung cancer patients treated with doxorubicin and cyclophosphamide at the same time the second course of treatment