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目的研究神经节苷脂ＧＭ１（ＧＭ１）对乙醇引起的神经膜磷脂的脂肪酸参入变化的影响。方法使用同位素标记的脂肪酸测定其对神经膜磷脂不同组分的参入率，比较ＧＭ１和乙醇对参入率的影响。结果慢性乙醇暴露改变了不饱和脂肪酸［油酸、亚油酸、花生四烯酸和二十二碳六烯酸（ＤＨＡ）］参入到磷脂酰肌醇、磷脂酰丝氨酸和磷脂酰胆碱。ＧＭ１的施用增强了乙醇引起的变化，特别是选择性地增加ＤＨＡ参入到磷脂酰乙醇胺和磷脂酰肌醇。结论ＧＭ１增强乙醇引起的神经膜磷脂的重酰化可能是一种损伤后修复机制。
Objective To investigate the effect of ganglioside GM1 (GM1) on the changes of fatty acids involved in the phospholipids induced by ethanol. Methods The isotope labeled fatty acids were used to determine the incorporation rate of different components of the phospholipids, and the effects of GM1 and ethanol on the rate of incorporation were compared. Results Chronic ethanol exposure altered the incorporation of unsaturated fatty acids [oleic acid, linoleic acid, arachidonic acid and docosahexaenoic acid (DHA)] into phosphatidylinositol, phosphatidylserine and phosphatidylcholine. The administration of GM1 enhances ethanol-induced changes, particularly selectively increasing the incorporation of DHA into phosphatidylethanolamine and phosphatidylinositol. Conclusion GM1 enhances the re-acylation of the phospholipid induced by ethanol may be a post-injury repair mechanism.