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为探讨脑啡肽与去甲肾上腺素一起参与血管运动的局部调节机制，用MTT法、氚标胸腺嘧啶脱氧核苷掺入法和斑点杂交技术发现亮氨酸脑啡肽可抑制SD大鼠胸主动脉平滑肌细胞的增殖、DNA合成和c-fos基因的表达；阿片受体阻断剂纳洛酮无上述抑制作用，但可拮抗亮氨酸脑啡肽的上述抑制作用；上述作用还可被去甲肾上腺素所拮抗。结果提示，脑啡肽通过影响血管平滑肌细胞功能来参与血管运动的局部调节，这种调节可能是通过阿片受体介导的。
In order to investigate the local regulation mechanism of enkephalin and norepinephrine involved in vasomotion, leucine enkephalin was detected by MTT, tritiated thymidine incorporation and dot blot hybridization Aortic smooth muscle cell proliferation, DNA synthesis and c-fos gene expression; naloxone, an opioid receptor blocker, does not inhibit the above-mentioned inhibition, but antagonizes the inhibitory effect of leucine enkephalin; the above effects can also be Norepinephrine is antagonized. The results suggest that enkephalin participates in the local regulation of vasomotion by affecting the function of vascular smooth muscle cells, and this regulation may be mediated by opioid receptors.