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血红素加氧酶-1(heme oxygenase-1,HO-1)是血红素分解代谢过程中的限速酶。HO-1及其降解产物(CO、胆绿素及Fe~(2+))能够通过各种途径调节机体免疫功能、抑制炎症反应和细胞凋亡,在消化系统疾病中发挥潜在的保护作用。该文综述了HO-1基因的表达和调节及其在胃肠道和肝病中的作用。
Heme oxygenase-1 (HO-1) is a rate-limiting enzyme in heme catabolism. HO-1 and its degradation products (CO, bilirubin and Fe 2+) can regulate the body’s immune function, inhibit the inflammatory reaction and apoptosis through various pathways and play a potential protective role in digestive diseases. This review summarizes the expression and regulation of HO-1 gene and its role in the gastrointestinal tract and liver disease.