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本文评价肺炎球菌菌苗在芬兰老年人中的免疫原性以及老年人对肺炎球菌荚膜多糖的抗体应答.作者将350名老年人(平均75.6岁,男性131名,女性219名)分成65～74岁、75～84岁和85岁以上3个年龄组,三角肌注射23价肺炎球菌茵苗,分别于接种前后采血,在加入过量的肺炎球菌细胞壁多糖(C-PS)中和血清中的抗C-PS抗体后,用酶免疫测定法(EIA)检测抗6个血清型(4、6B、9V、14、19F和23F型)的IgG抗体.同时,以56名未接种菌苗的健康献血者(平均32.3岁,男性29名.女性27名)作为对照组.
This article evaluates the immunogenicity of pneumococcal vaccine in elderly people in Finland and the antibody response to pneumococcal capsular polysaccharide in the elderly. The study randomized 350 elderly (mean 75.6 years, 131 males and 219 females) 74 years old, 75-84 years old and 85 years old over three age groups, deltoid muscle injection 23 price pneumococcal vaccine, respectively, before and after inoculation blood, adding excessive pneumococcal cell wall polysaccharide (C-PS) and serum Anti-C-PS antibodies were tested for IgG antibodies against 6 serotypes (4, 6B, 9V, 14, 19F and 23F) by enzyme immunoassay (EIA) Blood donors (average 32.3 years old, 29 males and 27 females) served as controls.