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目的初步探讨人参皂苷Rg1对幼鼠染铅所致学习记忆障碍的影响。方法选取21 d龄SD大鼠,随机分为5组:对照组,模型组,人参皂苷Rg1低、中和高剂量组。采用腹腔注射方式给幼鼠染毒和药物干预。通过Morris水迷宫试验,观察人参皂苷Rg1对染铅幼鼠定位航行能力和空间搜索能力的影响。石墨炉原子吸收光谱法测定血铅含量。结果模型组幼鼠与其他组相比寻找平台时间明显增加(P<0.05)。人参皂苷Rg1可降低染铅幼鼠血铅含量(P<0.05),45 mg/kg剂量人参皂苷Rg1可明显改善铅中毒大鼠的学习记忆。结论幼鼠轻度铅中毒即能导致学习记忆功能障碍。人参皂苷Rg1对铅致神经毒性起保护作用,能改善铅中毒幼鼠的空间学习记忆功能障碍。
Objective To investigate the effect of ginsenoside Rg1 on learning and memory impairment induced by lead exposure in young rats. Methods 21-day-old SD rats were randomly divided into 5 groups: control group, model group, ginsenoside Rg1 low, medium and high dose groups. Adopting intraperitoneal injection to young rats and drug intervention. Morris water maze test was conducted to observe the effect of ginsenoside Rg1 on the positioning, navigation ability and spatial search ability of young lead-exposed mice. Determination of Blood Lead by Graphite Furnace Atomic Absorption Spectrometry. Results Compared with other groups, the time of looking for platform in model group was significantly increased (P <0.05). Ginsenoside Rg1 could reduce the level of blood lead (P <0.05), and 45 mg / kg dose of ginsenoside Rg1 could significantly improve learning and memory in lead poisoning rats. Conclusion Young lead poisoning can lead to learning and memory dysfunction. Ginsenoside Rg1 can protect lead induced neurotoxicity and improve spatial learning and memory dysfunction in lead poisoning young rats.