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作者测定了每12周肌注醋酸甲孕酮(DMPA)150mg避孕的9名妇女周围血中醋酸甲孕酮(MP-A)、性激素结合蛋白(SHBG)和各种垂体及性腺激素浓度。所有对象均为26～41岁,使用DMPA避孕已达4.4～10.6年(平均8.9年),在注射DM-PA之前即刻,注后2周及下次注射前即刻分别取血,用RIA测血中MPA、17β-雌二醇、雌酮、睾丸酮、孕酮、FSH、LH和催乳素浓度。并测定SHBG水平,且以取自30例有正常月经妇女血浆中该值的百分比表示。用溴甲酚法测血浆白蛋白含量。结果表明注射DMPA2周内血浆雌二醇略降低(P<0.025),此后略有上升但仍为正常滤泡早水平,而雌酮无明显改变(P>0.05),血浆孕期
The authors measured progesterone acetate (MP-A), sex hormone binding protein (SHBG), and various concentrations of pituitary and gonadal hormones in peripheral blood of 9 women who contracted 150 mg of medroxyprogesterone acetate (DMPA) every 12 weeks. All subjects were 26 to 41 years of age, with DMPA contraception of 4.4 to 10.6 years (mean 8.9 years), immediately prior to DM-PA injection, 2 weeks after injection and immediately before the next injection, MPA, 17 [beta] -estradiol, estrone, testosterone, progesterone, FSH, LH and prolactin concentrations. SHBG levels were measured and expressed as a percentage of the plasma taken from 30 women with normal menstruation. Determination of albumin content with bromocresol method. The results showed that the plasma estradiol was slightly decreased (P <0.025) within 2 weeks after injection of DMPA, then slightly increased but remained normal early follicular level, while estrone had no significant change (P> 0.05)