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按3×3析因试验的方法将13～15g雄性昆明种小鼠分为9组,经饮水施加实验处理。碘(I)、氟(F)各选缺乏(D),适量(M)和过量(E)三个剂量,水碘浓度分别是0.0、20.0和2500.0μg/L,水氟浓度为0.0、0.6和30.0mg/L。实验发现①在100天氟可加强碘缺乏、抑制碘过量的致甲状腺肿能力,而150天氟加强过量碘、抑制碘缺乏的致甲胂作用;②在实验第30、60、90和150天,碘缺乏情况下氟对骨和牙的毒作用最强。
According to the method of 3 × 3 factorial test, 13 ~ 15g male Kunming mice were divided into 9 groups and experimentally treated with drinking water. The iodine (I), fluorine (F) selection of the lack of (D), the right amount (M) and the excess (E) three doses of water iodine concentrations were 0.0,20.0 and 2500.0μg / L, water fluoride concentration of 0.0,0.6 And 30.0 mg / L. The experiment found that ① on the 100th fluorine can enhance iodine deficiency, inhibition of excessive iodine induced goiter capacity, and 150 days of fluorine to strengthen excess iodine, inhibit the iodine deficiency induced methylarsine; ② on the experimental day 30,60,90 and 150 days In the case of iodine deficiency, fluoride has the strongest toxic effect on bone and teeth.