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目的 探讨幽门螺杆菌 (Hp)感染与格林 巴利综合征 (GBS)发病的相关性。方法 用免疫法对GBS及对照组血清、CSF进行Hp特异性IgA、IgG、IgM测定。结果 4 9例GBS血清IgG含量为 (4 8.6 2± 57.30 )U/L ,阳性率 6 7.3% ,对照组为 (12 .4 5± 15.0 7)U/L ,阳性率 35.9% ,经统计学检验 ,t=4 .87,x2 =8.55,P均 <0 .0 1;IgA分别为 (8.6 2± 9.19)U/L、(5.4 8± 4 .12 )U/L(t=3.6 4 ,P <0 .0 1) ;IgM分别为 (2 0 .58± 2 6 .4 3)U/L、(13.0 6± 17.52 )U/L(t=1.83,P >0 .0 5)。 2 1例GBSCSFHp特异性IgG为 (4 .19± 4 .2 1)U/L ,2 0例对照组为 (2 .2 1±0 .34)U/L(t=5.37,P <0 .0 1) ;IgA分别为 (2 .89± 1.2 1)U/L、(2 .54± 0 .6 7)U/L(t =1.84 ,P >0 .0 5) ;IgM分别为 (4 .4 1± 1.83)U/L、(3.98± 1.0 2 )U/L(t=1.2 6 ,P >0 .0 5)。结论 Hp抗体水平与GBS发病呈正相关 ,提示Hp感染可能是GBS发病诱因之一。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and the incidence of Guillain-Barre syndrome (GBS). Methods Serum and CSF of GBS and control group were tested by Hp specific IgA, IgG and IgM by immunoassay. Results The serum IgG level in 49 cases of GBS was (4 8.62 ± 57.30) U / L, the positive rate was 6 7.3%, while the control group was (12.45 ± 15.0 7) U / L, the positive rate was 35.9% Test, t = 4.87, x2 = 8.55, P <0.01; IgA were (8.62 ± 9.19) U / L and (5.48 ± 4.12) U / P <0.01). IgM was (20.58 ± 26.34) U / L and (13.0 6 ± 17.52) U / L respectively (t = 1.83, P> 0.05). The specific IgG of GBSCSFHp was (4.19 ± 4.21) U / L for 1 case of GBSCSFHp and (2.21 ± 0.34) U / L for 20 cases of control group (t = 5.37, P <0. (2 .89 ± 1.2 1) U / L, (2.54 ± 0.67) U / L (t = 1.84, P> 0.05) .4 1 ± 1.83) U / L, (3.98 ± 1.02) U / L (t = 1.2 6, P> 0.05). Conclusions The level of Hp antibody is positively correlated with the incidence of GBS, suggesting that Hp infection may be one of the causes of GBS.