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目的：探讨ｐ５３基因表达异常的意义。方法：用免疫组织化学方法研究ｐ５３基因蛋白在胃癌中的表达。结果：７２例胃腺癌中３６例（５０．０％）阳性，高分化腺癌（５３．３％）和低分化腺癌（５８．６％）ｐ５３阳性率明显高于粘液癌（２３．１％），不同浸润深度的癌细胞与癌细胞ｐ５３阳性程度有关（Ｐ＜０．０５），在淋巴结转移组和无转移组间ｐ５３阳性率和阳性程度均无显著差异（Ｐ＞０．０５），病人的生存时间与ｐ５３阳性程度无明显的相关性（ｒ＝０．１８３，Ｐ＞０．０５），癌旁肠上皮化生和异型增生腺体全部为阴性。结论：ｐ５３异常表达是细胞癌变的标志之一。
Objective: To investigate the significance of abnormal expression of p53 gene. Methods: The expression of p53 protein in gastric cancer was studied by immunohistochemistry. Results: Among 72 cases of gastric adenocarcinoma, 36 cases (50.0%) were positive, and the positive rate of p53 in well differentiated adenocarcinoma (53.3%) and poorly differentiated adenocarcinoma (58.6%) was significantly higher than that in mucinous carcinoma (23.1). %), Different depth of invasion of cancer cells and cancer cells p53 positive degree (P <0.05), in the lymph node metastasis group and no metastasis group p53 positive rate and positive degree were not significantly different (P> 0.05) There was no significant correlation between the patient’s survival time and the degree of p53 positive (r=0.183, P>0.05). The para-intestinal metaplasia and dysplasia glands were all negative. Conclusion: Abnormal expression of p53 is one of the hallmarks of cell carcinoma.