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目的:探讨2型糖尿病(T2DM)患者血清骨保护素(OPG)水平与骨密度(BMD)的相关性。方法:选取2014年1月至2016年1月在邯郸市中心医院治疗的T2DM患者114例,其中骨量正常组40例,骨量减少组35例,骨质疏松组39例。测定3组患者血清OPG水平以及其他生化指标。结果:3组患者性别、年龄、腰椎BMD、髋部BMD、腰椎T值、髋部T值、病程和OPG水平比较差异有统计学意义(P<0.05),其中骨质疏松组OPG水平为(6.81±1.17)pmol·L~(-1),明显高于其他两组(P<0.05);3组血清OPG水平与腰椎BMD及髋部BMD呈负相关(P<0.05);多元线性回归分析显示仅年龄、体质量指数和OPG水平与患者BMD有相关性(P<0.05)。结论:2型糖尿病患者血清OPG水平与BMD呈负相关,其中骨质疏松症患者OPG水平明显升高。
Objective: To investigate the correlation between serum osteoprotegerin (OPG) level and bone mineral density (BMD) in type 2 diabetes mellitus (T2DM). Methods: A total of 114 T2DM patients treated in Central Hospital of Handan from January 2014 to January 2016 were selected, including 40 cases with normal bone mass, 35 cases with osteopenia and 39 cases with osteoporosis. Serum OPG levels and other biochemical parameters were measured in 3 groups. Results: There were significant differences in gender, age, lumbar BMD, hip BMD, lumbar spine T value, hip T value, duration of disease and OPG between the three groups (P <0.05). The OPG level in osteoporosis group was 6.81 ± 1.17) pmol·L -1, significantly higher than the other two groups (P <0.05). There was a negative correlation between serum OPG level and lumbar spine BMD and hip BMD (P <0.05). Multiple linear regression analysis Only the age, body mass index and OPG level were correlated with BMD (P <0.05). Conclusion: The serum OPG level in patients with type 2 diabetes is negatively correlated with BMD, and the level of OPG in patients with osteoporosis is significantly higher.