【摘 要】
:
An efficient microwave-assisted palladium-catalyzed hydroxylation of aryl chloride with alkaline carbonate as base was developed.This protocol provides a fast conversion of aryl and heteroaryl chlorid
【出 处】
:
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
An efficient microwave-assisted palladium-catalyzed hydroxylation of aryl chloride with alkaline carbonate as base was developed.This protocol provides a fast conversion of aryl and heteroaryl chloride to phenols under microwave assistance and tolerates functional group such as keto,aldehyde,ester,nitrile,and amide.
其他文献
The catalytic asymmetric Michael addition of sulfones to nitroalkenes represents a straight-forward approach toward chiral nitroalkenes or cyclic nitrones bearing sulfone functionality in organic synt
A stepwise efficient protocol for the synthesis of flavones and γ-benzopyranones was developed.This protocol afforded substituted o-alkynoylphenol acetates intermediates in one pot reaction under mild
Oxindole alkaloids bearing a quaternary carbon stereocenter,especially spirooxindoles,represent a prevalent scaffold found in natural products and biologically active compounds.Ethyl 2-oxindoles-3-car
The synthesis of 3-alkyl-2-nitro-benzo[b]furans is the subject of intense investigation because the nitro group has a significant effect on the biological activity and often manifests changes in chemi
Benzisoxazole is a critical subunit in pharmaceuticals with important biological and pharmaceutical activities,1 including antipsychrotic,antitumor,antimicrobial and ehrolinesterase-inhibiting(Alzheim
An efficient traceless synthetic strategy for the soluble polymer supported synthesis of trisubstituted aminoimidazolone and disubstituted benzylidene-aminoimidazolone has been developed under microwa
Phenyl-piperazine is an important intermediate product of medicines.Reported synthesis methods of phenylpiperazine are as follows:cyclization of phenylamine and bis(2-chloroethyl) amine hydrochloride
Sulfur mustard,1,1-thiobis(2-chloroethane),is typically cytotoxic and vesicant agent due to its highly biological activity which is generally believed to stem from ability to function as an alkylating
The developing of new MCRs,1 and improving known multi-component reactions are an area of considerable current interest.One of such reactions,is the synthesis of imidazoles.Multi-substituted imidazole
Diclofenac acid is a non-steroidal anti-inflammatory drug which is a commonly used drug in our daily life.It is one of drugs used on clinical in great number for its wide uses and indication.NSAID is