Highly Efficient,Recoverable C3-Symmetric Cinchonine-Squaramide Catalyzed Michael Addition:An Approa

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：yaodanmeidan

【摘要】

：

【作者】

：

Xin Han Haibing Zhou Chune Dong

【机构】

：

School of Pharmaceutical Sciences,Wuhan University,Wuhan

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The catalytic asymmetric Michael addition of sulfones to nitroalkenes represents a straight-forward approach toward chiral nitroalkenes or cyclic nitrones bearing sulfone functionality in organic synthesis,which are extremely versatile building blocks for the construction of numerous natural products and pharmaceuticals as well.As a consequence of this,many different catalytic enantioselective versions of this fundamental transformation have been reported.

其他文献

Synthesis of Dapagliflozin's Structural Analogues as Potent and Selective Renal Sodium-dependen

The prevalence of diabetes throughout the world continues to increase and has become a major health issue.Recently there have been many reports about the inhibitors directed toward the sodium-dependen

会议

Synthesis of Novel 1,3-Diaryl Pyrazole Derivatives Bearing 3-Carboxyalkyl-rhodanine Moieties as Pote

The search for potent small molecule protein tyrosine phosphatase 1B inhibitors is a major thrust area in the management of type 2 diabetes mellitus and obesity.A useful and commonly adopted strategy

会议

Synthsis and Evaluation in vivo of Artemisinin-hydrazone Derivatives against Plasmodium berghei ANKA

Malaria still remains one of the major public health problems all over the world[1].Although artemisinin has been used successfully against chloroquine-resistant malarial parasites,its chemotherapeuti

会议

Synthesis,Separation and Antifungal Activity of Diastereoisomers of 2,3,3a,4-tetrahydropyrido[b]thio

The incidence of fungal infections has increased dramatically in recent years.The triazoles antifungal agents which act by inhibiting cytochrome P450 now became the most rapidly expanding group of ant

会议

tetrahydropyrido[b] thiopyran [43-c] pyrazole-2-carboxamidesynthesisantifunga

The Research on Anti-tumor Activity of Rubescens Active Ingredients and Triazole Derivatives of Orid

Cancer is a serious threat to human health and as its incidence increased rapidly in recent years,finding and developing anti-cancer drugs from natural products has become an important topic both dome

会议

The Synthesis of Pyrazole-based N-Substitued Rhodanine Derivatives and their Antibacterial Activity

An alarming increment in pathogenic resistance to existing first line standard drugs is a serious problem in antimicrobial cure and necessitates continuing research into new classes of antimicrobials

会议

Using a QSPR Approach to Develop Better Thiobenzanilide Scaffolds to Fight Tuberculosis

Tuberculosis,an infectious disease caused by Mycobacterium tuberculosis(M.tb),affects currently one third of the worlds population(data from WHO)1 and has become a serious threat to global health due

会议

thiobenzanilidesQSPRlogPcytotoxicity

Total Synthesis of Grassystatin A,a Probe for Cathepsin E Function

Cathepsin E(cath E) is an intracellular aspartic protease that is mainly present in the immune system.Cath E is highly homologous to the analogous aspartic protease cathepsin D(cath D).So far,the phys

会议

An Improved Synthesis of Methyl Protodioscin:A Direct E-ring Opening by BF3-Et2O/Ac2O from Dioscin E

A direct E-ring opening of dioscin ester by BF3-Et2O/Ac2O was studied,and methyl protodioscin was synthesized from dioscin ester in three steps with a total yield of 44%.The details of the E-ring open

会议

Asymmetric Synthesis of 3-Indolylglycines via Oxidative Heterocoupling Reaction of Chiral Ni(Ⅱ) Comp

3-Indolylglycine and its derivates are versatile motifs in natural products,asymmetric chemical investigations,medicinal and peptide/peptidomimetic chemistry and drug discovery.Despite the fact that t

会议

Highly Efficient,Recoverable C3-Symmetric Cinchonine-Squaramide Catalyzed Michael Addition:An Approa

其他学术论文