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Objective To run a meta-analysis to determine IL28B genotypes,rs12979860 CC correlation with outcome in hepatitis B and C patients,and development and evaluation of a novel Single-Nucleotide-Polymorphism Real-Time PCR assay for rapid detection of rs12979860 that predicts HCV therapy response.Method Meta-analysis was performed in 11 studies of rs12979860 CC vs.CT/TT in HCV research and 5 papers in the area of HBV infection.Odds ratios (OR) and confidence intervals (95 ％CI) were calculated by fixed-effects models.Heterogeneity,sensitivity analysis and publication bias were also assessed.TaqMan probe-based SNP real-time PCR increases allelic discrimination using two probes that only differ by one nucleotide.The sensitivity was as low as 1.5ng/μl,the amplification efficacy was 97.6 ％.