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Specific objectives:Previously,we showed that porcine monocytic cells could be skewed to various activation statuses similar to those described in mice and humans,including M 1 and M2.We hypothesize that the activation status of porcine monocytic cells,during PRRSV infection,provides a framework for optimizing antiviral immunity and immune homeostasis.The specific objectives of this study include:(1) genome-wide profiling of differentially expressed genes (DEGs) in PRRSV-infected porcine alveolar macrophages (PAMs);(2) compare the expression of classic marker genes associated with different activation statuses in PRRSV-infected PAMs;(3) perform a family-wide analysis of innate immunity and lipid metabolism genes during PRRSV infection;(4) define significant marker genes at different activation statuses for antiviral/homeostatic regulation in porcine monocytic cells.